A dual-agonist option for weight management and blood sugar control. Calculate your dose and follow the step-up schedule from 2.5 mg to 15 mg.
Pre-filled with typical tirzepatide values. Adjust to match your vial and protocol.
Tirzepatide is a first-in-class dual-agonist peptide developed by Eli Lilly that targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. It is approved as Mounjaro for type 2 diabetes and as Zepbound for chronic weight management.
The dual-agonist approach differentiates tirzepatide from single-agonist peptides like semaglutide. By activating both GLP-1 and GIP pathways, tirzepatide enhances insulin secretion, improves insulin sensitivity, reduces glucagon levels, slows gastric emptying, and modulates appetite through complementary mechanisms. Clinical trial data (SURMOUNT and SURPASS programs) demonstrated substantial weight reduction and metabolic improvements.
Below are common dosing protocols for tirzepatide based on available research and community experience:
| Protocol | Dose | Notes |
|---|---|---|
| Weeks 1-4 | 2.5 mg | Starting dose; establish tolerability |
| Weeks 5-8 | 5.0 mg | First escalation |
| Weeks 9-12 | 7.5 mg | Second escalation |
| Weeks 13-16 | 10.0 mg | Third escalation |
| Weeks 17-20 | 12.5 mg | Fourth escalation (if tolerated) |
| Week 21+ | 15.0 mg | Maximum approved dose |
Ready to calculate? Use the calculator above or our full calculator with syringe visualization.
Tirzepatide comes as a lyophilized (freeze-dried) powder that must be reconstituted with bacteriostatic water before use. The process is standard for all peptides:
For a detailed step-by-step guide with visuals, see our complete peptide reconstitution guide.
Understanding potential side effects helps you use tirzepatide more safely. Most side effects are dose-dependent and may improve over time.
Before reconstitution: Store lyophilized (powder) tirzepatide in a cool, dry place away from direct sunlight. Refrigeration is ideal for long-term storage of unreconstituted peptides.
After reconstitution: Store the reconstituted vial upright in a refrigerator at 36-46°F (2-8°C). Do not freeze. The solution typically remains stable for 4-6 weeks. Always swab the vial stopper with an alcohol pad before each use.
Because tirzepatide doses range from 2.5 mg to 15 mg, reconstitution math can vary significantly depending on your current dose. At lower doses (2.5-5 mg) with a 5 mg vial, you may get multiple doses per vial. At higher doses (10-15 mg), you may need larger vials or multiple vials per dose.
A common approach is to use 2 mL of BAC water per 5 mg vial, giving a concentration of 2.5 mg/mL. For a 2.5 mg dose, you would draw 1 mL (100 units). For a 5 mg dose, you would use the entire vial. Adjust the calculator above to match your specific vial size and target dose.
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