An on-demand peptide used for sexual health support. Calculate your dose and learn the usual timing window before use.
Pre-filled with typical pt-141 values. Adjust to match your vial and protocol.
PT-141 (bremelanotide) is a synthetic peptide derived from the melanocortin system. Unlike PDE5 inhibitors that work through vascular mechanisms, PT-141 acts directly on the central nervous system by activating melanocortin receptors (MC3R and MC4R) in the hypothalamus.
The FDA approved bremelanotide (branded as Vyleesi) in 2019 for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. However, research and anecdotal reports suggest it may be effective for both men and women. It is administered as needed via subcutaneous injection, typically 45-60 minutes before anticipated activity.
Below are common dosing protocols for pt-141 based on available research and community experience:
| Protocol | Dose | Notes |
|---|---|---|
| Standard Dose | 1.0-2.0 mg | 45-60 minutes before anticipated activity |
| First-time / Low Dose | 0.5-1.0 mg | Assess individual response and tolerability |
| Maximum Frequency | No more than 1 dose per 24 hours | Do not exceed 8 doses per month |
Ready to calculate? Use the calculator above or our full calculator with syringe visualization.
PT-141 comes as a lyophilized (freeze-dried) powder that must be reconstituted with bacteriostatic water before use. The process is standard for all peptides:
For a detailed step-by-step guide with visuals, see our complete peptide reconstitution guide.
Understanding potential side effects helps you use pt-141 more safely. Most side effects are dose-dependent and may improve over time.
Before reconstitution: Store lyophilized (powder) pt-141 in a cool, dry place away from direct sunlight. Refrigeration is ideal for long-term storage of unreconstituted peptides.
After reconstitution: Store the reconstituted vial upright in a refrigerator at 36-46°F (2-8°C). Do not freeze. The solution typically remains stable for 4-6 weeks. Always swab the vial stopper with an alcohol pad before each use.
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