A mitochondrial peptide used for energy, glucose control, and metabolic support. Calculate your dose and review common cycle structures.
Pre-filled with typical mots-c values. Adjust to match your vial and protocol.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a mitochondrial-derived peptide discovered in 2015 by researchers at the University of Southern California. It is a 16-amino-acid peptide encoded within the mitochondrial genome and represents a newly discovered class of signaling molecules that link mitochondrial function to whole-body metabolism.
MOTS-c has been described as an 'exercise mimetic' because it activates AMPK (a key metabolic sensor), improves glucose uptake in skeletal muscle, enhances fatty acid oxidation, and promotes metabolic homeostasis in ways that partially replicate the benefits of exercise. Research has shown its levels decline with age, correlating with metabolic dysfunction.
Below are common dosing protocols for mots-c based on available research and community experience:
| Protocol | Dose | Notes |
|---|---|---|
| Standard Protocol | 5-10 mg | 3-5x per week via subcutaneous injection |
| Performance Protocol | 10 mg | 5x per week (weekdays) for 4-8 weeks |
| Metabolic Support | 5 mg | 3x per week for 8-12 weeks |
Ready to calculate? Use the calculator above or our full calculator with syringe visualization.
MOTS-c comes as a lyophilized (freeze-dried) powder that must be reconstituted with bacteriostatic water before use. The process is standard for all peptides:
For a detailed step-by-step guide with visuals, see our complete peptide reconstitution guide.
Understanding potential side effects helps you use mots-c more safely. Most side effects are dose-dependent and may improve over time.
Before reconstitution: Store lyophilized (powder) mots-c in a cool, dry place away from direct sunlight. Refrigeration is ideal for long-term storage of unreconstituted peptides.
After reconstitution: Store the reconstituted vial upright in a refrigerator at 36-46°F (2-8°C). Do not freeze. The solution typically remains stable for 4-6 weeks. Always swab the vial stopper with an alcohol pad before each use.
Looking for a different peptide? Each calculator is pre-filled with standard dosing values.